Review
doi: 10.1016/j.ceb.2003.10.013.
Mitotic mechanics: the auroras come into view
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- PMID: 14644191
- DOI: 10.1016/j.ceb.2003.10.013
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Review
Mitotic mechanics: the auroras come into view
Curr Opin Cell Biol.
2003 Dec.
Abstract
Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.
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