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Review
. 2003 Dec;185(24):7031-5.
doi: 10.1128/JB.185.24.7031-7035.2003.

It is all about metabolic fluxes

Jens Nielsen  1
Affiliations
Review

It is all about metabolic fluxes

Jens Nielsen. J Bacteriol. 2003 Dec.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Frequency plot of the number of reactions that each metabolite appears in for four different reconstructed metabolic networks. For each metabolic network the 10 metabolites that appear in the most reactions are listed. PP, pyrophosphate; COA, coenzyme A. The numbers in the box specify the numbers of reactions the 10 most frequently used metabolites participate in for the four different microorganisms.
FIG. 2.
FIG. 2.
Illustration of how measurement of the 13C enrichment patterns can be used to identify active pathways. EMP, Embden-Meyerhof-Parnas; ED, Entner-Doudoroff; PP, pentose phosphate.
See this image and copyright information in PMC

Comment on

References

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    1. Cliften, P., P. Sudarsanam, A. Desikan, L. Fulton, B. Fulton, J. Majors, R. Waterston, B. A. Cohen, and M. Johnston 2003. Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science 301:71-76. - PubMed
    1. Covert, M. W., C. H. Schilling, I. Famili, J. S. Edwards, I. I. Goryanin, E. Selkov, and B. O. Palsson. 2001. Metabolic modeling of microbial strains in silico. Trends Biochem. Sci. 26:179-186. - PubMed
    1. dos Santos, M. M., A. K. Gombert, B. Christensen, L. Olsson, and J. Nielsen. 2003. Identification of in vivo enzyme activities in the co-metabolism of glucose and acetate by Saccharomyces cerevisiae using 13C-labeled substrates. Eukaryot. Cell 2:599-608. - PMC - PubMed

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