Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Dec 1;89(11):2078-86.
doi: 10.1038/sj.bjc.6601296.

Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20-44 years: the UK National Case-Control Study of Cervical Cancer

J Green  1 , A Berrington de Gonzalez, S Sweetland, V Beral, C Chilvers, B Crossley, J Deacon, C Hermon, P Jha, D Mant, J Peto, M Pike, M P Vessey
Affiliations

Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20-44 years: the UK National Case-Control Study of Cervical Cancer

J Green et al. Br J Cancer. .

Abstract

We report results on risk factors for invasive squamous cell and adenocarcinomas of the cervix in women aged 20-44 years from the UK National Case-Control Study of Cervical Cancer, including 180 women with adenocarcinoma, 391 women with squamous cell carcinoma and 923 population controls. The risk of both squamous cell and adenocarcinoma was strongly related to the lifetime number of sexual partners, and, independently, to age at first intercourse. The risk of both types of cervical cancer increased with increasing duration of use of oral contraceptives, and this effect was most marked in current and recent users of oral contraceptives. The risk of squamous cell carcinoma was associated with high parity and the risk of both squamous cell and adenocarcinoma increased with early age at first birth. Long duration smoking (20 or more years) was associated with a two-fold increase in the risk of squamous cell carcinoma, but smoking was not associated with the risk of adenocarcinoma. Further studies are needed to confirm the suggestion from this and other studies of differences in risk related to smoking between squamous cell and adenocarcinomas of the cervix.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Altekruse SF, Lacey JVJ, Brinton LA, Gravitt PE, Silverberg SG, Barnes WAJ, Greenberg MD, Hadjimichael OC, McGowan L, Mortel R, Schwartz PE, Hildesheim A (2003) Comparison of human papillomavirus genotypes, sexual, and reproductive risk factors of cervical adenocarcinoma and squamous cell carcinoma: Northeastern United States. Am J Obstet Gynecol 188: 657–663 - PubMed
    1. Andersson S, Rylander E, Larsson B, Strand A, Silfversvard C, Wilander E (2001) The role of human papillomavirus in cervical adenocarcinoma carcinogenesis. Eur J Cancer 37: 246–250 - PubMed
    1. Bergstrom R, Sparen P, Adami HO (1999) Trends in cancer of the cervix uteri in Sweden following cytological screening. Br J Cancer 81: 159–166 - PMC - PubMed
    1. Berrington A, Jha PK, Peto J, Green J, Hermon C (2002) Oral contraceptives and cervical cancer. Lancet 360: 410 - PubMed
    1. Bjorge T, Kravdal O (1996) Reproductive variables and risk of uterine cervical cancer in Norwegian registry data. Cancer Causes Control 7: 351–357 - PubMed

Substances