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. 2003 Dec 1;89(11):2116-21.
doi: 10.1038/sj.bjc.6601372.

Matrix metalloproteinase-7 and matrix metalloproteinase-9 are associated with unfavourable prognosis in superficial oesophageal cancer

Affiliations

Matrix metalloproteinase-7 and matrix metalloproteinase-9 are associated with unfavourable prognosis in superficial oesophageal cancer

Y Tanioka et al. Br J Cancer. .

Abstract

If oesophageal carcinoma is detected in the superficial stage, the prognosis is better than for advanced oesophageal carcinoma. But the factors which predict the prognosis and treatment policy remain unclear. Matrix metalloproteinase-7 (MMP-7) and matrix metalloproteinase-9 (MMP-9) have been reported to have close associations with tumour invasion and metastasis. In this study, we retrospectively studied the relations between MMP-7 and MMP-9 expression in immunohistochemistry, clinicopathologic factors, and prognosis in 55 superficial oesophageal carcinomas. MMP-7 and MMP-9 expression occurred in 23.6% and 47.3% of the patients, respectively. MMP-7 expression was significantly correlated with the presence of nodal metastasis (P=0.004). MMP-9 expression was significantly correlated with the depth of tumour invasion (P=0.004), lymphatic permeation (P=0.001), nodal metastasis (P=0.049), and pathologic differentiation grade (P=0.003). By the log-rank test, MMP-7 expression and MMP-9 expression on the invasive front were related to the prognosis. In multivariate analysis, MMP-9 expression on the invasive front was an independent prognostic indicator. The combined expression of MMP-7 and MMP-9 may be a good marker for the degree of malignancy of oesophageal cancer and for the presence of lymphatic metastasis.

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Figures

Figure 1
Figure 1
Immunohistochemical staining of oesophageal cancer for MMP-7 and MMP-9. (A) MMP-7-positive SCC; MMP-7 was stained in cancer cell cytoplasm, (B) MMP-7-negative SCC, (C) MMP-9-positive SCC; MMP-9 was stained in tumour cytoplasm, (D) MMP-9-negative SCC (× 400).
Figure 2
Figure 2
Comparison of overall survival curves for patients with MMP-7-positive and MMP-7-negative superficial oesophageal cancer. MMP-7-positive patients have a less favourable prognosis than those who are MMP-7-negative.
Figure 3
Figure 3
Comparison of overall survival curves for patients with MMP-9-positive and MMP-9-negative superficial oesophageal cancer. Patients who were MMP-9-positive at the invasive front had a less favourable prognosis than those who were MMP-9-negative at the invasive front.

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