Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003;4(2-3):115-20.
doi: 10.1023/a:1026174727482.

Protein crystallization for genomics: throughput versus output

Naomi E Chayen  1
Affiliations
Review

Protein crystallization for genomics: throughput versus output

Naomi E Chayen. J Struct Funct Genomics. 2003.

Abstract

Structural genomics involves many steps in order to reach from Gene to structure. This article focuses on the crystallization step in this chain of tasks. It is becoming increasingly evident that the current high throughput procedures for crystallising proteins do not always produce the expected output of high quality crystals required for structure determination by x-ray crystallography. This problem is discussed and suggestions for raising the output are presented.

PubMed Disclaimer

References

    1. Drug Discov Today. 2002 Feb 1;7(3):187-96 - PubMed
    1. J Cell Biochem. 1982;19(2):145-55 - PubMed
    1. Protein Eng. 1996 Oct;9(10):927-9 - PubMed
    1. Trends Biotechnol. 2002 Mar;20(3):98 - PubMed
    1. Anal Chem. 2002 Jul 15;74(14):3505-10 - PubMed

Publication types

LinkOut - more resources