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. 2003 Dec 26;312(4):1357-63.
doi: 10.1016/j.bbrc.2003.11.066.

The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

Sandrine Funes  1 , Joseph A Hedrick, Galya Vassileva, Lisa Markowitz, Susan Abbondanzo, Andrei Golovko, Shijun Yang, Frederick J Monsma, Eric L Gustafson
Affiliations

The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

Sandrine Funes et al. Biochem Biophys Res Commun. .

Abstract

GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene. KiSS-1 has been shown to have anti-metastatic effects, suggesting that KiSS-1 or its receptor represents a potential therapeutic target. To further our understanding of the physiological function of this receptor, we have generated a mutant mouse line with a targeted disruption of the GPR54 receptor (GPR54 -/-). The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features. These data suggest a role for GPR54/KiSS-1 in normal sexual development, and indicate that study of the GPR54 mutant mice may provide valuable insights into human reproductive syndromes.

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