Integration of multiple motor segments for the elaboration of locomotion: role of the fastigial nucleus of the cerebellum

Abstract

This chapter provides a conceptual overview of the role and operation of higher structures of the central nervous system (CNS) in the control of posture and locomotion in the mammal, including the nonhuman primate and the human. Both quadrupedal and bipedal locomotion require the integrated neural control of multiple body segments against gravity. During development, and in selected instances in the adult, motor learning is required, particularly for merging anticipatory and reactive CNS processes, the latter being necessary after tripping and stumbling. We have recently found that the fastigial nucleus (FN) of the cerebellum in the cat plays a particularly important role in the control of locomotion, by virtue of its critical position in uniting the cerebro-cerebellar and the spino-cerebellar loops of neural activity that participate in the integrated control of multiple body segments. Further understanding of the CNS structures that achieve this integration has come from our recent study of an intact nonhuman primate, the Japanese monkey, Macaca fuscata, as it learns to elaborate bipedal locomotion rather than its normal quadrupedal fashion. Based on findings from these two animal species, we now present a model of the overall integrated control of posture and locomotion that features the combined operation of parallel and distributed neural circuitry throughout the CNS.