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Case Reports
. 1992 May-Jun;84(1091):363-9.

[Non-radioactive in situ hybridization of alpha-satellite sequences in cytogenetic diagnosis]

[Article in Italian]
C Perfumo  1 , A Arslanian, F Zara, G Piombo, M Pierluigi
Affiliations
  • PMID: 1465321
Case Reports

[Non-radioactive in situ hybridization of alpha-satellite sequences in cytogenetic diagnosis]

[Article in Italian]
C Perfumo et al. Pathologica. 1992 May-Jun.

Abstract

Non isotopic in situ hybridization with alpha-satellite DNA probes in the cytogenetic diagnosis. Standard banding cytogenetic techniques do not always allow to define the structure and the origin of chromosome rearrangements involving the centromere region. Non-isotopic in situ hybridization of alphoid sequences has allowed to determine the origin of the centromeres in the metaphases of 5 patients referred to us for: 2 structural rearrangements involving chromosome 21, 2 structural rearrangements involving chromosome Y and 1 reciprocal translocation involving on chromosome 20 and one chromosome 15.

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