Review
doi: 10.1016/j.tips.2003.10.006.
Interleukin 4 treatment of psoriasis: are pleiotropic cytokines suitable therapies for autoimmune diseases?
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- PMID: 14654299
- DOI: 10.1016/j.tips.2003.10.006
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Review
Interleukin 4 treatment of psoriasis: are pleiotropic cytokines suitable therapies for autoimmune diseases?
Trends Pharmacol Sci.
2003 Dec.
Abstract
Many human autoimmune diseases are still treated by a combination of corticosteroids and general immunosuppression. A better understanding of the pathogenesis of these diseases has led to therapies that are more specific than current therapies of some of these disorders. In psoriasis, T helper (Th) cells with a pro-inflammatory phenotype (Th1) are considered essential to the disease process. A recent clinical trial of interleukin 4 in psoriasis has demonstrated that such pleiotropic cytokines can be used safely and effectively to correct imbalances in immune function.
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