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. 1992 Dec 15;89(24):12028-32.
doi: 10.1073/pnas.89.24.12028.

Wild-type p53 binds to the TATA-binding protein and represses transcription

E Seto  1 , A Usheva, G P Zambetti, J Momand, N Horikoshi, R Weinmann, A J Levine, T Shenk
Affiliations

Wild-type p53 binds to the TATA-binding protein and represses transcription

E Seto et al. Proc Natl Acad Sci U S A. .

Abstract

p53 activates transcription of genes with a p53 response element, and it can repress genes lacking the element. Here we demonstrate that wild-type but not mutant p53 inhibits transcription in a HeLa nuclear extract from minimal promoters. Wild-type but not mutant p53 binds to human TATA-binding protein (TBP). p53 does not bind to yeast TBP, and it cannot inhibit transcription in a HeLa extract where yeast TBP substitutes for human TBP. These results suggest a model in which p53 binds to TBP and interferes with transcriptional initiation.

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