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. 1992 Dec 15;89(24):12103-7.
doi: 10.1073/pnas.89.24.12103.

Patterns of spatiotemporal organization in an "ambiquitous" enzyme model

P Marmillot  1 , J F Hervagault, G R Welch
Affiliations

Patterns of spatiotemporal organization in an "ambiquitous" enzyme model

P Marmillot et al. Proc Natl Acad Sci U S A. .

Abstract

Many enzymes in pathways such as glycolysis associate reversibly with cellular substructures. The spatiotemporal behavior of a "limit-cycle" oscillation model is studied under the condition that the "ambiquitous" oscillophor, phosphofructokinase, is partitioned between "bulk-phase" and "bound" forms in a heterogeneous system. Computer simulation demonstrates the occurrence of sustained, wave-like spatiotemporal patterns of chemical concentration in the bulk medium. Kinetic dissimilarity among the localized populations of bound enzyme leads to a "polarity" effect in the wave phenomenon. It is suggested that a key physiological role of the limit-cycle regime is to engender a rapid, site-to-site, signal-transmission modality in large eukaryotic (e.g., mammalian) cells.

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