doi: 10.1021/jo0347359.
The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles
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- PMID: 14656087
- DOI: 10.1021/jo0347359
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The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles
J Org Chem.
.
Abstract
The unprecedented application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed in a full account. Our efforts in broadening the applicability of chiral pyrrolidine-based catalysts in direct asymmetric Mannich-type reactions led to the highly diastereo- and enantioselective and concise synthesis of functionalized alpha- and beta-amino acids, beta-lactams, and amino alcohols.
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