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. 2003 Dec 12;68(25):9624-34.
doi: 10.1021/jo0347359.

The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles

Wolfgang Notz  1 , Fujie Tanaka, Shin-Ichi Watanabe, Naidu S Chowdari, James M Turner, Rajeswari Thayumanavan, Carlos F Barbas 3rd
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The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles

Wolfgang Notz et al. J Org Chem. .

Abstract

The unprecedented application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed in a full account. Our efforts in broadening the applicability of chiral pyrrolidine-based catalysts in direct asymmetric Mannich-type reactions led to the highly diastereo- and enantioselective and concise synthesis of functionalized alpha- and beta-amino acids, beta-lactams, and amino alcohols.

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