doi: 10.1021/jo034976g.
N-tritylprolinal: an efficient building block for the stereoselective synthesis of proline-derived amino alcohols
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- PMID: 14656102
- DOI: 10.1021/jo034976g
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N-tritylprolinal: an efficient building block for the stereoselective synthesis of proline-derived amino alcohols
J Org Chem.
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Abstract
N-Tritylprolinal (prepared in four steps from l-proline) shows a very high Felkin diastereoselectivity in its reaction with various nucleophiles, leading to a straightforward and highly stereoselective access to syn-proline-derived amino alcohols.
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