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. 2003 Dec 12;68(25):9747-52.
doi: 10.1021/jo034976g.

N-tritylprolinal: an efficient building block for the stereoselective synthesis of proline-derived amino alcohols

Joseph Bejjani  1 , Fabrice Chemla, Max Audouin
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N-tritylprolinal: an efficient building block for the stereoselective synthesis of proline-derived amino alcohols

Joseph Bejjani et al. J Org Chem. .

Abstract

N-Tritylprolinal (prepared in four steps from l-proline) shows a very high Felkin diastereoselectivity in its reaction with various nucleophiles, leading to a straightforward and highly stereoselective access to syn-proline-derived amino alcohols.

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