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Case Reports
. 2004 Feb;163(2):81-4.
doi: 10.1007/s00431-003-1372-y. Epub 2003 Dec 5.

Protein-losing gastroenteropathy and retinitis associated with cytomegalovirus infection in an immunocompetent infant: a case report

Manabu Iwanaga  1 , Masafumi Zaitsu, Eiichi Ishii, Yoichi Nishimura, Shigeyasu Inada, Hiroka Yoshiki, Satoshi Okinami, Yuhei Hamasaki
Affiliations
Case Reports

Protein-losing gastroenteropathy and retinitis associated with cytomegalovirus infection in an immunocompetent infant: a case report

Manabu Iwanaga et al. Eur J Pediatr. 2004 Feb.

Abstract

A 6-week-old immunocompetent girl developed protein-losing gastroenteropathy (PLGE) and retinitis associated with cytomegalovirus (CMV) infection. At presentation, CMV antigenaemia (6 cells/46,000 white blood cells) and its DNA were detected in the patient's blood and in the mother's milk. Intravenous ganciclovir and gamma-globulin rapidly ameliorated all symptoms and CMV antigenaemia disappeared. No immunological defects were identified in this patient. To the best of our knowledge, this case involves the youngest known immunocompetent patient demonstrating CMV-induced PLGE and retinitis.

Conclusion: breast-feeding by a cytomegalovirus-positive mother can be a primary cause of early onset cytomegalovirus infection in infants.

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References

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