[Memory and potassium channels]
- PMID: 14658300
[Memory and potassium channels]
Abstract
The K(+)-channels of the surface membrane play a crucial role in the generation of electrical activity of a neuron. There is a large diversity of the K(+)-channels that depends on a great number (over 200) of genes encoding channels proteins. An evolutionary conservation of channel's proteins is determined. The K(+)-channels were found to have a great importance in the memory processes. It was shown on different model systems that K(+)-current of the surface membrane decreases during the learning. The antagonists of K(+)-channels were found to improve the learning and memory. It was revealed in electrophysiological experiments that K(+)-channels antagonists can either themselves induce a long-term synaptic potentiation or intensify the synaptic potentiation induced by a tetanization. The disfunction of K(+)-channels is believed to be an important link in the mechanisms of memory disturbances. In animal mutants with K(+)-channels disfunction, learning and memory are deficient. In behavioral experiments, the use of K(+)-channels openers make the learning worse. Amnesia caused by cerebral ischemia is explained by strong activity of K(+)-channels which not only inhibits neuronal excitement but also causes neurodegeneration. The question on the K(+)-channels involvement into pathophysiology of Alzheimer's disease is discussed. Neurotoxic peptide beta-amyloid, which is supposed to be involved into mechanisms of Alzheimer's disease, modulates K(+)-channels function. The effect of beta-amyloid depends on the subtype of K(+)-channels: A-channels are inhibited, and KDR-channels, on the contrary, become stronger. The effect of the cognitive enhancers (vinpocetine, piracetam, tacrine, linopirdine) on K(+)-current also depends on the subtype of K(+)-channels. Slow-inactivating K(+)-currents (IDR, IK(Ca), IM) are inhibited in the presence of these drugs, while fast-in-activating K(+)-current (A-current) remains unchanged or even increases.
Similar articles
-
Effects of amyloid peptides on A-type K+ currents of Drosophila larval cholinergic neurons.J Neurobiol. 2006 Apr;66(5):476-87. doi: 10.1002/neu.20227. J Neurobiol. 2006. PMID: 16470685
-
Newly developed blockers of the M-current do not reduce spike frequency adaptation in cultured mouse sympathetic neurons.Eur J Neurosci. 2004 May;19(10):2693-702. doi: 10.1111/j.1460-9568.2004.03363.x. Eur J Neurosci. 2004. PMID: 15147303
-
Donepezil is a strong antagonist of voltage-gated calcium and potassium channels in molluscan neurons.Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jan;144(4):319-26. doi: 10.1016/j.cbpc.2006.10.001. Epub 2006 Oct 19. Comp Biochem Physiol C Toxicol Pharmacol. 2007. PMID: 17126610
-
Voltage-gated K+ channel modulators as neuroprotective agents.Life Sci. 2010 May 22;86(21-22):775-80. doi: 10.1016/j.lfs.2010.04.004. Epub 2010 Apr 10. Life Sci. 2010. PMID: 20385147 Review.
-
Enhancing synaptic plasticity and memory: a role for small-conductance Ca(2+)-activated K+ channels.Neuroscientist. 2003 Dec;9(6):434-9. doi: 10.1177/1073858403259282. Neuroscientist. 2003. PMID: 14678575 Review.
Cited by
-
Enhancement of neuronal outward delayed rectifier K+ current by human monocyte-derived macrophages.Glia. 2009 Nov 1;57(14):1492-500. doi: 10.1002/glia.20865. Glia. 2009. PMID: 19306367 Free PMC article.
-
4-Aminopyridine improves spatial memory in a murine model of HIV-1 encephalitis.J Neuroimmune Pharmacol. 2009 Sep;4(3):317-27. doi: 10.1007/s11481-009-9161-7. Epub 2009 May 23. J Neuroimmune Pharmacol. 2009. PMID: 19462247 Free PMC article.
-
HIV-1 Tat alters neuronal intrinsic excitability.BMC Res Notes. 2018 May 4;11(1):275. doi: 10.1186/s13104-018-3376-8. BMC Res Notes. 2018. PMID: 29728138 Free PMC article.
-
The Relieving Effects of BrainPower Advanced, a Dietary Supplement, in Older Adults with Subjective Memory Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial.Evid Based Complement Alternat Med. 2016;2016:7898093. doi: 10.1155/2016/7898093. Epub 2016 Apr 11. Evid Based Complement Alternat Med. 2016. PMID: 27190539 Free PMC article.
-
Voltage-gated potassium channels in human immunodeficiency virus type-1 (HIV-1)-associated neurocognitive disorders.J Neuroimmune Pharmacol. 2009 Mar;4(1):60-70. doi: 10.1007/s11481-008-9106-6. Epub 2008 May 6. J Neuroimmune Pharmacol. 2009. PMID: 18459047 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical