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Review
. 2003;4(12):238.
doi: 10.1186/gb-2003-4-12-238. Epub 2003 Nov 18.

The draft genome sequence of the nematode Caenorhabditis briggsae, a companion to C. elegans

Bhagwati P Gupta  1 , Paul W Sternberg
Affiliations
Review

The draft genome sequence of the nematode Caenorhabditis briggsae, a companion to C. elegans

Bhagwati P Gupta et al. Genome Biol. 2003.

Abstract

The publication of the draft genome sequence of Caenorhabditis briggsae improves the annotation of the genome of its close relative Caenorhabditis elegans and will facilitate comparative genomics and the study of the evolutionary changes during development.

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Figures

Figure 1
Figure 1
Anatomical comparison of C. briggsae and C. elegans. (a) The C. briggsae hermaphrodite. (b, c)Vulval invagination in L4 larvae of (b) C. elegans and (c) C. briggsae. The vulval morphology of C. briggsae is almost indistinguishable from that of C. elegans; minor differences include a slightly thicker vulval-uterine connection (utse) in C. briggsae.
Figure 2
Figure 2
The phylogenetic relationship of C. briggsae with other nematodes (modified from [3,6]). Oscheius tipulae (family Rhabditida) and Pristionchus pacificus (Diplogasterida) are two other models used to study evolutionary changes during development [31].
Figure 3
Figure 3
A pie chart showing the relationship between C. briggsae and C. elegans genes. BLASTP matches and conserved gene order (synteny) have revealed 62% of C. briggsae genes to have orthologs in C. elegans. About 27% of C. briggsae genes have multiple matches in C. elegans genome and represent various gene families. Of the remaining 11% of genes, 7% have very weak similarity to C. elegans (with a BLASTP E value of over 10-5), whereas 4% appear to be unique.
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