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Review
. 2003 Dec 4;40(5):881-4.
doi: 10.1016/s0896-6273(03)00757-8.

Bringing order to the glutamate chaos in schizophrenia

Bita Moghaddam  1
Affiliations
Free article
Review

Bringing order to the glutamate chaos in schizophrenia

Bita Moghaddam. Neuron. .
Free article

Abstract

Recent genetic linkage studies complement the existing evidence that implicates abnormalities in NMDA receptor-mediated neurotransmission in the pathophysiology of schizophrenia. At the same time, advances in our understanding of the complex mechanisms that modulate the function of NMDA receptors suggest several novel sites for pharmacological manipulation of these receptors. This presents exciting opportunities for rational rather than serendipitous discovery of therapeutics for schizophrenia.

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