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. 1978 Feb 15;34(2):236-7.
doi: 10.1007/BF01944701.

Type III (Arthus) allergic reactions and endotoxin toxicity in guinea-pigs

A J McLean, J Dowling

Type III (Arthus) allergic reactions and endotoxin toxicity in guinea-pigs

A J McLean et al. Experientia. .

Abstract

Lipoplysaccharide (endotoxin) from E. coli cells produced lethal effects in guinea-pigs. Endotoxin caused no visible dermal change in normal animals, but produced skin reactions characterized by specific Arthus-type (Type III immune hypersensitivity) vascular inflammation in immunized animals. It is concluded that Arthus allergic reactions were evoked by endotoxin, however, endotoxin lethal toxicity appears independent of this process.

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