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. 2003 Nov;22(2):81-4.
doi: 10.1385/ENDO:22:2:81.

Heparanase, galectin-3, and tissue factor mRNA are expressed in benign neoplasms of the thyroid

Andreas E Buchs  1 , Sergei Zehavi, Osnat Sher, Eyal Yeheskely, Michael Muggia-Sulam, Yoav Sherman, Micha J Rapoport
Affiliations

Heparanase, galectin-3, and tissue factor mRNA are expressed in benign neoplasms of the thyroid

Andreas E Buchs et al. Endocrine. 2003 Nov.

Abstract

Objective: Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs).

Design and methods: Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assessed by RT-PCR.

Results: Isolated expressions of heparanase and galectin- 3 mRNA were expressed in 2 and 4 of the 15 MNGs, respectively; 8/15 MNGs were positive for both heparanase and galectin-3. TF mRNA was found in all MNG specimens.

Conclusion: Galectin-3, heparanase, and TF RNA expression is prevalent in MNGs. Further studies will be needed to determine the prognostic significance of these findings.

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