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Review
. 2003 Nov;4(5):329-30.
doi: 10.1016/s1535-6108(03)00277-0.

Homeobox genes and cancer: new OCTaves for an old tune

Cory Abate-Shen  1
Affiliations
Free article
Review

Homeobox genes and cancer: new OCTaves for an old tune

Cory Abate-Shen. Cancer Cell. 2003 Nov.
Free article

Abstract

In this issue of Cancer Cell, Gidekel et al. demonstrate that Oct-4, a member of the POU class of homeobox genes, is a critical player in the genesis of testicular germ cell tumors. This study provides further evidence that deregulated expression of homeobox genes, which occurs in many solid tumors, is functionally relevant for carcinogenesis and highlights unique features that distinguish homeobox genes from other cancer-promoting genes.

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