Modeling transformation and metastasis in Drosophila

Abstract

Transformation and metastasis are complex, multistep processes. Two recent papers exploit powerful Drosophila genetics techniques to explore cooperation between multiple genetic manipulations and to model these processes. In particular, oncogenic Ras is found to collaborate with disruption of cell polarity to trigger massive neoplasia and metastasis. These studies promise further progress in research into the causes of cancer.