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. 1992 Dec;5(5-6):279-82.
doi: 10.1111/j.1574-6968.1992.tb05912.x.

Transferrin synthesis by macrophages: up-regulation by gamma-interferon and effect on lymphocyte proliferation

A Djeha  1 , J L Pérez-Arellano, S L Hayes, J H Brock
Affiliations

Transferrin synthesis by macrophages: up-regulation by gamma-interferon and effect on lymphocyte proliferation

A Djeha et al. FEMS Microbiol Immunol. 1992 Dec.

Abstract

We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose-dependent increase in response to gamma-interferon (gamma-IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.

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