doi: 10.1016/j.antiviral.2003.08.002.
Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells
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- PMID: 14670596
- DOI: 10.1016/j.antiviral.2003.08.002
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Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells
Antiviral Res.
2004 Jan.
Abstract
Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis.
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