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. 2004 Jan;61(1):67-70.
doi: 10.1016/j.antiviral.2003.08.002.

Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells

Nathalie Dereuddre-Bosquet  1 , Béatrice Roy, Kate Routledge, Pascal Clayette, Georges Foucault, Michel Lepoivre
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Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells

Nathalie Dereuddre-Bosquet et al. Antiviral Res. 2004 Jan.

Abstract

Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis.

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