Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Feb 1;147(2):605-10.
doi: 10.1084/jem.147.2.605.

Antibody-dependent cellular cytotoxicity by allosensitized human T cells

R L Evans, L Chess, H Levine, S F Schlossman

Antibody-dependent cellular cytotoxicity by allosensitized human T cells

R L Evans et al. J Exp Med. .

Abstract

Peripheral human T cells, isolated by sheep erythrocyte-rosette formation and density centrifugation, were highly cytotoxic to both Ab-coated autologous lymphocytes and antibody (Ab)-coated chicken erythrocytes when stimulated in mixed lymphocyte culture, but were not lytic when freshly purified, or when unstimulated in 6-day culture. Allosensitized T cells were shown to effect this activity by a specific effector-target cell interaction dependent on Ab, as indicated by: (a) induction of killing by Ab to target cells not lysed in the absence of Ab. (b) inhibition of Ab-dependent killing by aggregated Ig. The mechanism by which allosensitized T cells effect antibody-dependent cellular cytotoxicity is discussed.

PubMed Disclaimer

References

    1. J Exp Med. 1976 Jul 1;144(1):113-22 - PubMed
    1. J Exp Med. 1975 Feb 1;141(2):287-96 - PubMed
    1. Clin Immunol Immunopathol. 1975 Sep;4(3):415-24 - PubMed
    1. J Exp Med. 1976 Jul 1;144(1):54-68 - PubMed
    1. J Immunol. 1977 Jun;118(6):2058-66 - PubMed

Publication types