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doi: 10.1016/s0092-8674(03)00981-4.
Coupled folding during translation initiation
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- PMID: 14675529
- DOI: 10.1016/s0092-8674(03)00981-4
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Comment
Coupled folding during translation initiation
Cell.
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Free article
Abstract
The structure of the eukaryotic initiation factor eIF4E bound to a cognate domain of eIF4G and m(7)GDP in this issue of Cell shows that these factors undergo coupled folding to form a stable complex with high cap binding activity that promotes efficient ribosomal attachment to mRNA during translation initiation.
Comment on
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Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E.Cell. 2003 Dec 12;115(6):739-50. doi: 10.1016/s0092-8674(03)00975-9. Cell. 2003. PMID: 14675538
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