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. 2003 Dec 18;555(3):631-7.
doi: 10.1016/s0014-5793(03)01343-7.

Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation

Joris Hoeks  1 , Matthijs K C Hesselink, Marc van Bilsen, Gert Schaart, Ger J van der Vusse, Wim H M Saris, Patrick Schrauwen
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Free article

Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation

Joris Hoeks et al. FEBS Lett. .
Free article

Abstract

We compared UCP3 protein in rat cardiac, glycolytic and oxidative skeletal muscle and examined the effect of high-fat medium chain vs. long chain triacylglycerol feeding on UCP3 content in these tissues. Cardiac muscle displays the lowest basal levels of UCP3 protein. Increasing long chain - but not medium chain - fatty acid supply upregulates UCP3 in all muscles. Since plasma non-esterified fatty acids and the expression of two peroxisome proliferator-activated receptor (PPAR)-responsive genes, were not different between groups, we conclude that the differential upregulation of UCP3 is not merely PPAR-mediated. This study supports a role of UCP3 in export of non-metabolizable fatty acids.

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