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Case Reports
. 2003 Dec;22(6):491-2.
doi: 10.1007/s10067-003-0791-5. Epub 2003 Nov 4.

Churg-Strauss syndrome (CSS) in a patient receiving pranlukast

Shigeto Kobayashi  1 , Shyugo Ishizuka, Naoto Tamura, Makiyo Takaya, Kazuhiko Kaneda, Hiroshi Hashimoto
Affiliations
Case Reports

Churg-Strauss syndrome (CSS) in a patient receiving pranlukast

Shigeto Kobayashi et al. Clin Rheumatol. 2003 Dec.

Abstract

Pranlukast is a cysteinyl leukotriene receptor I antagonist (LTRAs) approved for treatment of asthma in Japan since 1995. Compared to other LTRAs, such as zafilukast and montelukast, only few cases with Churg-Strauss syndrome (CSS) have been reported in association with treatment with pranlukast. We describe a 17-year-old Japanese male patient who developed CSS with a 13 month history of mild asthma receiving pranlukast for 11 months without systemic and/or inhaled corticosteroid administration prior to development of CSS. From the aspect of temporal relationship between treatment with pranlukast and development of CSS, a direct induction of CSS by pranlukast is suggested in our case.

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