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. 2003 Dec 24;125(51):15700-1.
doi: 10.1021/ja038025w.

Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai

Masaki Fujita  1 , Yoichi Nakao, Shigeki Matsunaga, Motoharu Seiki, Yoshifumi Itoh, Jun Yamashita, Rob W M Van Soest, Nobuhiro Fusetani
Affiliations

Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai

Masaki Fujita et al. J Am Chem Soc. .

Abstract

A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine.

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