doi: 10.1021/ja036344h.
Design of a cyclic peptide that targets a viral RNA
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- PMID: 14677935
- DOI: 10.1021/ja036344h
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Design of a cyclic peptide that targets a viral RNA
J Am Chem Soc.
.
Abstract
The Tat protein controls transcription in lentiviruses such as HIV. A cyclic peptide analog of the RNA binding domain of the bovine immunodeficiency virus (BIV) Tat protein is shown to bind specifically to its target RNA stem loop. NMR data indicate a similar mode of binding of linear and cyclic peptides.
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