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. 2004 Jan;186(1):248-52.
doi: 10.1128/JB.186.1.248-252.2004.

Transcriptome analysis of the response of Pseudomonas aeruginosa to hydrogen peroxide

Marco Palma  1 , Darrow DeLuca, Stefan Worgall, Luis E N Quadri
Affiliations

Transcriptome analysis of the response of Pseudomonas aeruginosa to hydrogen peroxide

Marco Palma et al. J Bacteriol. 2004 Jan.

Abstract

Pseudomonas aeruginosa must often overcome a high concentration of oxidants to successfully infect the human host. We report here the results of a transcriptome profiling comparing cells treated with H(2)O(2) and untreated controls. The data indicate that the early response of P. aeruginosa to H(2)O(2) consists of an upregulation of protective mechanisms and a downregulation of primary metabolism.

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Figures

FIG. 1.
FIG. 1.
Functional classification of genes with mRNA level changes of fivefold or more. The percentage of genes whose mRNA levels increased with treatment per functional class (closed bars) is relative to the total number of genes displaying ≥5-fold mRNA level increase with treatment. The percentage of genes whose mRNA levels decrease with treatment per functional class (open bars) is relative to the total number of genes displaying ≥5-fold mRNA level decrease with treatment. Functional classes are taken from http://www.pseudomonas.com/current_annotation.asp.
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