[Arterial hypertension as a complication and risk factors of progression of chronic renal failure in children]

Abstract

Arterial hypertension is both a complication of chronic renal failure (crf) and one of the main risk factors of progression of crf. Investigations led in last 20 years enabled discovery of self-perpetuating mechanisms of crf progression and explained the role of arterial hypertension as one of the main risk factors of progression to end stage renal disease. Proposed in 80-ies and 90-ies years of XX-th century theories of hyperfiltration and proteinuria toxicity became the basis for renoprotective therapy in crf. Despite lack of large clinical trials held in children with crf, the principles of renoprotection in children with crf are also proposed. The relation between blood pressure, proteinuria and progression of crf is causing that concerning crf patients, term "hypotensive therapy" more often is replaced by the term "renoprotective therapy".