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Review
. 2004 Jan;4(1):74-82.
doi: 10.1007/s11882-004-0047-8.

Chemokines in eosinophil-associated gastrointestinal disorders

Simon P Hogan  1 , Marc E Rothenberg, Elizabeth Forbes, Vanessa E Smart, Klaus I Matthaei, Paul S Foster
Affiliations
Review

Chemokines in eosinophil-associated gastrointestinal disorders

Simon P Hogan et al. Curr Allergy Asthma Rep. 2004 Jan.

Abstract

Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.

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