Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1992 Oct;12(5):357-66.
doi: 10.1007/BF00711538.

Invertebrate and vertebrate neuroimmune and autoimmunoregulatory commonalties involving opioid peptides

G B Stefano  1
Affiliations
Review

Invertebrate and vertebrate neuroimmune and autoimmunoregulatory commonalties involving opioid peptides

G B Stefano. Cell Mol Neurobiol. 1992 Oct.

Abstract

1. Evidence for bidirectional interrelationships between the nervous system and immune systems of vertebrates and invertebrates involving opioid peptides is briefly discussed. 2. The involvement of opioid peptides in autoimmunoregulatory communication also is discussed. 3. The presence of mammalian interleukin-like (1 & 6) and tumor necrosis factor-like molecules in invertebrates is reviewed as well as an apparent cascading system for these signal molecules. 4. The significance of ACTH and MSH in cellular immunosuppression and autoimmunoregulation is discussed in the context of a potential role in schistosomiasis and human immunodeficiency virus actions. 5. The review concludes with the hypothesis that the mammalian immune system has its origin in the invertebrate immune/defense system given the many similarities noted in the review based on new knowledge about the more "primitive" system.

PubMed Disclaimer

References

    1. Beck, G., and Habicht, G. S. (1986). Isolation and characterization of a primitive interleukin-1 like protein from an invertebrate, Asterias forbesi.Proc. Natl. Acad. Sci. USA837429–7433. - PMC - PubMed
    1. Beck, G., Vasta, G. R., Marchalonis, J. J., and Habicht, G. S. (1989). Characterization of interleukin-1 activity in tunicates.Comp. Biochem. Physiol.9293–98. - PubMed
    1. Brown, S. L., and Van Epps, D. E. (1985). Suppression ofT-Iymphocyte chemotactic factor production by the opioid peptides beta-endorphin and Met-enkephalin.J. Immunol.1343384–3388. - PubMed
    1. Brown, S. L., Tokuda, S., Saland, L. C., and Van Epps, D. E. (1986). Opioid peptide effects on leukocyte migration. InEnkephalins and Endorphins Stress and the Immune System (N. P. Plotnikoff, R. E. Faith, A. J. Murgo, and R. Good, Eds.), Plenum Press, New York, pp. 367–386.
    1. Committee on Models for Biomedical Research (1985).Models for Biomedical Research: A New Perspective, Natl. Acad. Sci. Press, Washington, D.C.

Publication types

LinkOut - more resources