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. 2004 Jan 1;32(Database issue):D344-6.
doi: 10.1093/nar/gkh049.

TcruziDB: an integrated Trypanosoma cruzi genome resource

Michael Luchtan  1 , Chetna Warade, D Brent Weatherly, Wim M Degrave, Rick L Tarleton, Jessica C Kissinger
Affiliations

TcruziDB: an integrated Trypanosoma cruzi genome resource

Michael Luchtan et al. Nucleic Acids Res. .

Abstract

TcruziDB (http://TcruziDB.org) is an integrated genome database for the parasitic organism Trypanosoma cruzi, the causative agent of Chagas' disease. The database currently incorporates all available sequence data (Genomic, BAC, EST) in a single user-friendly location. The database contains a variety of tools specifically designed for searching unannotated draft sequence via BLAST, keyword searches of pre-computed BLAST results, and protein motif searches. Release 1.0 of the database contains nearly 730 million bp of genome sequence from 1.1 million sequence reads generated by the TIGR-Karolinska-SBRI Trypanosoma cruzi Genome Consortium and 15 million bp of clustered EST and genomic sequence obtained from other sources. As annotation, microarray and proteomic data become available, the database will incorporate and integrate these data using the GUS (http://www.gusdb. org) relational framework.

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Figures

Figure 1
Figure 1
Composite of screen displays demonstrating features of TcruziDB. (A) Front page of the website. The lower left-hand corner shows the sequence retrieval tool, SRT. (B) Sample multiple sequence alignment generated from BLAST results using the application Mview. A portion of a mucin protein sequence was used to search the database with BLASTP.
See this image and copyright information in PMC

References

    1. Zingales B., Rondinelli,E., Degrave,W., Da Silveira,J.F., Levin,M.J., Le Paslier,D., Modabber,F., Dobrokhotov,B., Swindle,J., Kelly,J.M. et al. (1996) The Trypanosoma cruzi Genome Consortium. Parasitol. Today, 13, 16–22.
    1. Cano M.I., Gruber,A., Vazquez,M., Cortes,A., Levin,M.J., Gonzalez,A., Degrave,W., Rondinelli,E., Zingales,B., Ramirez,J.L. et al. (1995) Molecular karyotype of clone CL Brener chosen for the Trypanosoma cruzi Genome Project. Mol. Biochem. Parasitol., 71, 273–278. - PubMed
    1. Degrave W., de Miranda,A.B., Amorim,A., Brandao,A., Aslett,M. and Vandeyar,M. (1997) TcruziDB, an integrated database and the WWW information server for the Trypanosoma cruzi genome project. Mem. Inst. Oswaldo Cruz, 92, 805–809. - PubMed
    1. Aguero F., Verdun,R.E., Frasch,A.C. and Sanchez,D.O. (2000) A random sequencing approach for the analysis of the Trypanosoma cruzi genome: general structure, large gene and repetitive DNA families and gene discovery. Genome Res., 10, 1996–2005. - PMC - PubMed
    1. Brown N.P., Leroy,C. and Sander,C. (1998) MView: a web-compatible database search or multiple alignment viewer. Bioinformatics, 14, 380–381. - PubMed

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