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. 2004 Jan 1;32(Database issue):D449-51.
doi: 10.1093/nar/gkh086.

The Database of Interacting Proteins: 2004 update

Affiliations

The Database of Interacting Proteins: 2004 update

Lukasz Salwinski et al. Nucleic Acids Res. .

Abstract

The Database of Interacting Proteins (http://dip.doe-mbi.ucla.edu) aims to integrate the diverse body of experimental evidence on protein-protein interactions into a single, easily accessible online database. Because the reliability of experimental evidence varies widely, methods of quality assessment have been developed and utilized to identify the most reliable subset of the interactions. This CORE set can be used as a reference when evaluating the reliability of high-throughput protein-protein interaction data sets, for development of prediction methods, as well as in the studies of the properties of protein interaction networks.

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Figures

Figure 1
Figure 1
A simplified entity-relationship diagram showing the key tables (rectangles) and relations (lines) of the DIP database. Dashed lines represent relationships that are used to describe the topology of protein complexes. PK, primary keys; FK, foreign keys. The full specification of the database is available at http://dip.doe-mbi.ucla.edu/Guide.cgi.

References

    1. Xenarios I., Rice,D.W., Salwinski,L., Baron,M.K., Marcotte,E.M. and Eisenberg,D. (2000) DIP: the Database of Interacting Proteins. Nucleic Acids Res., 28, 289–291. - PMC - PubMed
    1. Ito T., Chiba,T., Ozawa,R., Yoshida,M., Hattori,M. and Sakaki,Y. (2001) A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc. Natl Acad. Sci. USA, 98, 4569–4574. - PMC - PubMed
    1. Uetz P., Giot,L., Cagney,G., Mansfield,T.A., Judson,R.S., Knight,J.R., Lockshon,D., Narayan,V., Srinivasan,M., Pochart,P. et al. (2000) A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae. Nature, 403, 623–627. - PubMed
    1. Gavin A.C., Bosche,M., Krause,R., Grandi,P., Marzioch,M., Bauer,A., Schultz,J., Rick,J.M., Michon,A.M., Cruciat,C.M. et al. (2002) Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature, 415, 141–147. - PubMed
    1. Ho Y., Gruhler,A., Heilbut,A., Bader,G.D., Moore,L., Adams,S.L., Millar,A., Taylor,P., Bennett,K., Boutilier,K. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature, 415, 180–183. - PubMed

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