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. 1977 Dec 29;18(2-3):109-15.
doi: 10.1007/BF00280276.

The role of glutathione in renal cortical tissue. Effects of diamide on Na+ and GSSG levels, amino acid transport and Na+-K+-ATPase activity

D J Pillon, L Moree, H Rocha, D H Pashley, J Mendicino, F H Leibach

The role of glutathione in renal cortical tissue. Effects of diamide on Na+ and GSSG levels, amino acid transport and Na+-K+-ATPase activity

D J Pillon et al. Mol Cell Biochem. .

Abstract

The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na+-K+-ATPase activity. Consistent with this finding was the observation that diamide compromised the sodium gradients maintained in renal cortical slices. Amino acid transport studies with ouabain or a sodium-free buffer indicated that diamide interferes with both Na+-dependent and Na+-independent transport systems. These results indicate that diamide has a number of different effects on renal cortical tissue and emphasize the important role of glutathione in maintaining control of a number of key metabolic pathways.

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