Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Dec 26;68(26):10020-9.
doi: 10.1021/jo035332b.

Total syntheses of variolin B and deoxyvariolin B

Abderaouf Ahaidar  1 , David Fernández, Gerardo Danelón, Carmen Cuevas, Ignacio Manzanares, Fernando Albericio, John A Joule, Mercedes Alvarez
Affiliations

Total syntheses of variolin B and deoxyvariolin B

Abderaouf Ahaidar et al. J Org Chem. .

Abstract

Two alternative synthetic routes have been developed for the preparation of variolin B and deoxyvariolin B. The strategy is based on the preparation of the core tricyclic ring common to all variolins, pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine, followed by a palladium-catalyzed cross-coupling reaction to give the tetracyclic system.

PubMed Disclaimer

Publication types

MeSH terms