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. 2004 Jan 5;14(1):21-4.
doi: 10.1016/j.bmcl.2003.10.030.

Design and SAR of thienopyrimidine and thienopyridine inhibitors of VEGFR-2 kinase activity

Michael J Munchhof  1 , Jean S Beebe, Jeffery M Casavant, Beth A Cooper, Jonathan L Doty, R Carla Higdon, Stephen M Hillerman, Catherine I Soderstrom, Elisabeth A Knauth, Matthew A Marx, Ann Marie K Rossi, Susan B Sobolov, Jianmin Sun
Affiliations

Design and SAR of thienopyrimidine and thienopyridine inhibitors of VEGFR-2 kinase activity

Michael J Munchhof et al. Bioorg Med Chem Lett. .

Abstract

Novel classes of thienopyrimidines and thienopyridines have been identified as potent inhibitors of VEGFR-2 kinase. The synthesis and SAR of these compounds is presented, along with successful efforts to diminish EGFR activity present in the lead series.

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