Mapping by waves. Patterned spontaneous activity regulates retinotopic map refinement
- PMID: 14687538
- DOI: 10.1016/s0896-6273(03)00808-0
Mapping by waves. Patterned spontaneous activity regulates retinotopic map refinement
Abstract
A role for spontaneous spiking activity in shaping neuronal circuits has frequently been debated. Analyses of retinotopy in mutant mice with reduced correlated firing among neighboring retinal cells by Grubb et al. and McLaughlin et al. in this issue of Neuron indicate the importance of patterned spontaneous activity for retinotopic map refinement in subcortical visual targets.
Comment on
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Retinotopic map refinement requires spontaneous retinal waves during a brief critical period of development.Neuron. 2003 Dec 18;40(6):1147-60. doi: 10.1016/s0896-6273(03)00790-6. Neuron. 2003. PMID: 14687549
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Abnormal functional organization in the dorsal lateral geniculate nucleus of mice lacking the beta 2 subunit of the nicotinic acetylcholine receptor.Neuron. 2003 Dec 18;40(6):1161-72. doi: 10.1016/s0896-6273(03)00789-x. Neuron. 2003. PMID: 14687550
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