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Review
. 2004 Feb;5(1):1-8.
doi: 10.1007/s10048-003-0170-z. Epub 2003 Dec 19.

Friedreich ataxia-update on pathogenesis and possible therapies

Max Voncken  1 , Panos Ioannou, Martin B Delatycki
Affiliations
Review

Friedreich ataxia-update on pathogenesis and possible therapies

Max Voncken et al. Neurogenetics. 2004 Feb.

Abstract

Friedreich ataxia is the most-common inherited ataxia. Since the causative genetic basis was described in 1996, much has been learnt about the pathogenesis from human, animal, and yeast studies. This has led to the development of rational therapeutic approaches. In this review, the current state of knowledge regarding the pathogenesis of Friedreich ataxia is presented and possible therapeutic strategies based on this knowledge are discussed.

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