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. 2003 Dec 15;37(12):1705-10.
doi: 10.1086/379771. Epub 2003 Nov 19.

Human metapneumovirus-associated lower respiratory tract infections among hospitalized human immunodeficiency virus type 1 (HIV-1)-infected and HIV-1-uninfected African infants

Shabir A Madhi  1 , Herbert Ludewick, Yacine Abed, Keith P Klugman, Guy Boivin
Affiliations

Human metapneumovirus-associated lower respiratory tract infections among hospitalized human immunodeficiency virus type 1 (HIV-1)-infected and HIV-1-uninfected African infants

Shabir A Madhi et al. Clin Infect Dis. .

Erratum in

  • Clin Infect Dis. 2004 Apr 15;38(8):1201

Abstract

Respiratory tract infections due to human metapneumovirus (hMPV) have been reported worldwide, with the exception of Africa. The prevalence of hMPV infection was studied among human immunodeficiency virus type 1 (HIV-1)-infected and HIV-1-uninfected African infants who were hospitalized for lower respiratory tract infections (LRTIs). Nasopharyngeal aspirate samples obtained from 81 HIV-1-infected and 110 HIV-1-uninfected infants who had tested negative for other respiratory viruses were selected for investigation. hMPV was detected in 10 HIV-1-uninfected infants (9.1%) and 3 HIV-1-infected infants (3.7%). Compared with the entire cohort of HIV-1-uninfected infants, hMPV was 4.6-fold less common than respiratory syncytial virus, but it was 3.2-fold more common than influenza virus and 2.1-fold more common than parainfluenza virus types 1-3. Genotyping of 7 of 14 isolates revealed the circulation of 2 major phylogenetic groups of the virus, which were similar to those described in North America and Europe.

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Figures

Table 1
Table 1
Clinical characteristics of African infants with human metapneumovirus–associated severe lower respiratory tract infection.
Figure 1
Figure 1
Phylogram obtained from analysis of the fusion gene open-reading frame (nucleotide 700–1088) of 7 human metapneumovirus (hmpv) isolates recovered from subjects in South Africa and The Netherlands (hmpv00-1; GenBank accession no. AF371337).
Table 2
Table 2
Relative importance of human metapneumovirus (hMPV), in relation to other common respiratory viruses, among infants hospitalized for lower respiratory tract infection.
See this image and copyright information in PMC

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