Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Jan;48(1):1-14.
doi: 10.1128/AAC.48.1.1-14.2004.

Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes

R Bonnet  1
Affiliations
Review

Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes

R Bonnet. Antimicrob Agents Chemother. 2004 Jan.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Dendrogram of CTX-M family. Branch lengths are scaled according to the amino acid changes (94). The numbers at the major branch points refer to the number of times that a particular node was found in 1,000 bootstrap replications. a, designated UOE-1 and CTX-M-11 in GenBank (accession numbers AY013478 and AJ310929, respectively); b, designated MEN-1 (8)(GenBank accession number AAB22638); c, designated CTX-M-18 (74), UOE-2, and Toho-3 (GenBank accession numbers AF325133, AF311345, and AB038771, respectively); d, encoded by the blaKLUA-1, blaKLUA-3, blaKLUA-4, and blaKLUA-12 genes; e, designated KLUA-2 (45) (GenBank accession number AJ251722); *, the Toho-2 sequence was included i the CTX-M-9 group for the reasons described in references and .
FIG. 2.
FIG. 2.
Comparison of sequences surrounding the blaCTX-M genes in the chromosome of K. ascorbata (A) and in plasmid-mediated genes associated with ISEcp1 (B) or inserted in complex class I integrons InS21 and In35 (C) and In60 (D) (4, 34, 45, 84, 86). pb, base pairs.
See this image and copyright information in PMC

References

    1. Alobwede, I., F. H. M'Zali, D. M. Livermore, J. Heritage, N. Todd, and P. M. Hawkey. 2003. CTX-M extended-spectrum beta-lactamase arrives in the UK. J. Antimicrob. Chemother. 51:470-471. - PubMed
    1. Ambler, R. P., A. F. W. Coulson, J.-M. Frére, J. M. Ghuysen, B. Joris, M. Forsman, R. C. Lévesque, G. Tiraby, and S. G. Waley. 1991. A standard numbering scheme for the class A β-lactamases. Biochem. J. 276:269-272. - PMC - PubMed
    1. Arakawa, Y., M. Ohta, N. Kido, M. Mori, H. Ito, T. Komatsu, Y. Fujii, and N. Kato. 1989. Chromosomal β-lactamase of Klebsiella oxytoca, a new class A enzyme that hydrolyzes broad-spectrum β-lactam antibiotics. Antimicrob. Agents Chemother. 33:63-70. - PMC - PubMed
    1. Arduino, S. M., P. H. Roy, G. A. Jacoby, B. E. Orman, S. A. Pineiro, and D. Centron. 2002. blaCTX-M-2 is located in an unusual class 1 integron (In35) which includes Orf513. Antimicrob. Agents Chemother. 46:2303-2306. - PMC - PubMed
    1. Baraniak, A., J. Fiett, A. Sulikowska, W. Hryniewicz, and M. Gniadkowski. 2002. Countrywide spread of CTX-M-3 extended-spectrum beta-lactamase-producing microorganisms of the family Enterobacteriaceae in Poland. Antimicrob. Agents Chemother. 46:151-159. - PMC - PubMed

Substances

LinkOut - more resources