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Clinical Trial
. 2004 Jan;88(1):17-8.
doi: 10.1136/bjo.88.1.17.

Mitomycin C as an adjunct in the treatment of localised ocular surface squamous neoplasia

C Chen  1 , D Louis, T Dodd, J Muecke
Affiliations
Clinical Trial

Mitomycin C as an adjunct in the treatment of localised ocular surface squamous neoplasia

C Chen et al. Br J Ophthalmol. 2004 Jan.

Abstract

Aim: To report the outcome of topical mitomycin C (MMC) used as adjunctive treatment following primary excision of ocular surface squamous neoplasia (OSSN).

Method: Prospective, non-comparative interventional case series of 27 primary OSSN lesions from 26 patients treated in a single ocular oncology centre over a 4 year period.

Result: 27 cases of OSSN received a treatment regimen of surgical excision, followed by topical MMC. Mean follow up of 27 (SD 12) months (range 12-50, median 25 months) revealed zero recurrences.

Conclusion: MMC treatment following surgical excision decreases the recurrence rate of primary ocular surface neoplasia and should be considered as adjunctive therapy in primary treatment.

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