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Case Reports
. 2003 Dec 23;61(12):1814-6.
doi: 10.1212/01.wnl.0000098996.02934.86.

Chronic neuropathy with IgM anti-ganglioside antibodies: lack of long term response to rituximab

R Rojas-García  1 , E Gallardo, I de Andrés, N de Luna, C Juarez, P Sánchez, I Illa
Affiliations
Case Reports

Chronic neuropathy with IgM anti-ganglioside antibodies: lack of long term response to rituximab

R Rojas-García et al. Neurology. .

Abstract

Two patients with chronic motor neuropathy, high antiganglioside antibody (AGA) titers, and a declining response to IV immunoglobulins were treated with rituximab at a standard dose. The drug was well tolerated and effectively eliminated peripheral B cells (CD20+), but AGA titers continued significantly high. No clinical improvement was detected during the 1-year follow-up.

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