Review
doi: 10.1002/cbic.200300721.
Chemical strategies for activity-based proteomics
Affiliations
- PMID: 14695510
- DOI: 10.1002/cbic.200300721
Item in Clipboard
Review
Chemical strategies for activity-based proteomics
Chembiochem.
.
Abstract
The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity-based protein profiling enable both the discovery and functional analysis of enzymes associated with human disease.
Similar articles
-
Enzyme inhibitor discovery by activity-based protein profiling.Annu Rev Biochem. 2014;83:341-77. doi: 10.1146/annurev-biochem-060713-035708. Annu Rev Biochem. 2014. PMID: 24905785 Review.
-
A tandem orthogonal proteolysis strategy for high-content chemical proteomics.J Am Chem Soc. 2005 Jul 20;127(28):10018-9. doi: 10.1021/ja0532842. J Am Chem Soc. 2005. PMID: 16011363 Free PMC article.
-
Activity-based proteomics of lipolytic enzymes.Curr Drug Discov Technol. 2007 Jun;4(1):1-11. doi: 10.2174/157016307781115458. Curr Drug Discov Technol. 2007. PMID: 17630923 Review.
-
Activity-based proteomics: enzymatic activity profiling in complex proteomes.Amino Acids. 2006 Jun;30(4):333-50. doi: 10.1007/s00726-006-0305-2. Epub 2006 May 15. Amino Acids. 2006. PMID: 16773240 Review.
-
The development and application of methods for activity-based protein profiling.Curr Opin Chem Biol. 2004 Feb;8(1):54-9. doi: 10.1016/j.cbpa.2003.11.004. Curr Opin Chem Biol. 2004. PMID: 15036157 Review.
Cited by
-
Polycarcin V induces DNA-damage response and enables the profiling of DNA-binding proteins.Natl Sci Rev. 2022 Mar 11;9(11):nwac046. doi: 10.1093/nsr/nwac046. eCollection 2022 Nov. Natl Sci Rev. 2022. PMID: 36601137 Free PMC article.
-
Small Molecule Active Site Directed Tools for Studying Human Caspases.Chem Rev. 2015 Nov 25;115(22):12546-629. doi: 10.1021/acs.chemrev.5b00434. Epub 2015 Nov 9. Chem Rev. 2015. PMID: 26551511 Free PMC article. Review.
-
"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.J Am Chem Soc. 2018 Jan 10;140(1):200-210. doi: 10.1021/jacs.7b08366. Epub 2017 Dec 21. J Am Chem Soc. 2018. PMID: 29265822 Free PMC article.
-
Hunting down the shapeshifters.Nat Chem Biol. 2023 Dec;19(12):1438-1439. doi: 10.1038/s41589-023-01407-1. Nat Chem Biol. 2023. PMID: 37653168 No abstract available.
-
Development of Noninvasive Activity-Based Protein Profiling-Bioluminescence Resonance Energy Transfer Platform Technology Enables Target Engagement Studies with Absolute Specificity in Living Systems.ACS Pharmacol Transl Sci. 2024 Jan 4;7(2):375-383. doi: 10.1021/acsptsci.3c00231. eCollection 2024 Feb 9. ACS Pharmacol Transl Sci. 2024. PMID: 38357276 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
