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. 2004 Jan 1;47(1):10-3.
doi: 10.1021/jm034189b.

Self-association of okadaic acid upon complexation with potassium ion

Antonio H Daranas  1 , José J Fernández, Ezequiel Q Morales, Manuel Norte, José A Gavín
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Self-association of okadaic acid upon complexation with potassium ion

Antonio H Daranas et al. J Med Chem. .

Abstract

Okadaic acid (OA) is a toxin responsible for diarrhetic shellfish poisoning and is an extremely useful tool for studying processes that are regulated by phosphorylation, although the exact mechanism of action is still undetermined. We report on a study that proved the existence of OA in an unusual dimeric form when complexed with potassium ion. The proposed structure of this dimer is based on spectroscopic and conformational studies.

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