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Comment
. 2003 Dec 26;115(7):768-70.
doi: 10.1016/s0092-8674(03)01019-5.

The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death

Pierluigi Nicotera  1 , Daniele Bano
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The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death

Pierluigi Nicotera et al. Cell. .
Free article

Abstract

In brain ischemia, gating of postsynaptic glutamate receptors is thought to initiate Ca2+ overload leading to excitotoxic neuronal death. In this issue, Aarts and colleagues describe a novel mechanism, whereby gating of TRPM7, a Ca2+-permeable nonselective cation channel, mediates Ca2+ overload and demise of anoxic neurons.

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