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Comparative Study
. 2004 Jan 19;14(2):329-32.
doi: 10.1016/j.bmcl.2003.11.020.

Synthesis of galactopyranosyl amino alcohols as a new class of antitubercular and antifungal agents

Neetu Tewari  1 , V K Tiwari, R P Tripathi, V Chaturvedi, A Srivastava, R Srivastava, P K Shukla, A K Chaturvedi, A Gaikwad, S Sinha, B S Srivastava
Affiliations
Comparative Study

Synthesis of galactopyranosyl amino alcohols as a new class of antitubercular and antifungal agents

Neetu Tewari et al. Bioorg Med Chem Lett. .

Abstract

The galactopyranosyl amino alcohols (3-16) were synthesised by regioselective oxirane ring opening of compound 2 with variety of amines and screened for antitubercular and antifungal activities. One of the compounds (16) showed potent activity against Mycobacterium tuberculosis H37 Rv in vitro and also displayed activity in MDR TB. The compound (16) was found to be superior to ethambutol clinically used anti TB drug in in vitro screen.

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